Protests across Syria reach Ghouta, when thousands who gather to protest in Douma are met with live gunfire, killing at least three of the protesters.
Rebel factions expel government forces from eastern Ghouta towns.
Backed by Lebanese Hezbollah, government forces advance around eastern Ghouta and capture the strategic town of al-Otaiba, placing the enclave under siege.
Government forces close key crossing points in Mleha and Douma, preventing residents from leaving the enclave.
Government forces launch sarin-laden rockets at eastern Ghouta and rebel-held southwestern suburbs of Damascus, killing at least 1,429 people according to US government estimates.
The first instance of death due to a lack of medicine in eastern Ghouta is recorded.
Deir al-Asafir pocket is captured by the Syrian government. Farmland that helped sustain eastern Ghouta through the previous years of the siege is lost.
Syrian government forces capture the areas al-Qaboun and Barzeh, bordering Harasta, closing all smuggling tunnels that for years provided a supply corridor for food, water, and medical supplies, barely managing to sustain the opposition-held enclave.
The Syrian government closes al-Wafideen crossing, the last remaining entry point into Douma, tightening the siege and sending the enclave into a humanitarian crisis. Only a handful of shipments of goods would subsequently enter, skyrocketing the costs of basic goods in eastern Ghouta.
Syrian forces capture Deir al-Zour from the Islamic State of Iraq and al-Sham (ISIS), freeing up forces for redeployment elsewhere in the country.
Additional Tiger Forces arrive in eastern Ghouta, many converging on the rebel enclave after battling ISIS near Deir al-Zour.
The Syrian government and allied forces commence their military offensive against the eastern pocket, marking the beginning of Operation Damascus Steel.
The United Nations Security Council passes UNSC Resolution 2401, calling for an immediate cease-fire with a thirty-day humanitarian pause.
The ground assault on eastern Ghouta begins, with the main fighting vectors on the southeastern front lines and around the Harasta vehicle base.
Russia announces a daily five-hour humanitarian pause for civilians to pass through al-Wafideen crossing, but artillery shelling persists during these pauses. Only two civilians were recorded to have passed through the crossing in the days following the announcement.
The regime takes Hawsh Dawahirah, a heavily fortified position in the southeastern area of the pocket, as heavy bombardment covers Syrian Arab Army advances.
Humanitarian aid is allowed into eastern Ghouta for the first time since the beginning of the offensive, but government air strikes prevent completion of the aid delivery and the United Nations aid convoy is forced to retreat.
Remaining food from the previous convoy is delivered.
All of Mesraba is lost to pro-government forces. The Syrian army splits eastern Ghouta into two pockets, taking full control of Madira and the Harasta-Ghouta-west link. Douma remains attached to Harasta. Shortly after, the link between Harasta and Douma is severed by advancing regime forces.
An aid convoy is allowed into Douma with twenty-five trucks, marking the second convoy since the commencement of the assault on eastern Ghouta. Civilians begin fleeing in large numbers the eastern Ghouta pocket, with thousands crossing into government-held Damascus from Hammouriya. By the end of the ground operation, 92,235 people would flee into government-run internally displaced person (IDP) centers.
A displacement deal is reached for Harasta as the first of now three eastern Ghouta enclaves fall to the SAA and its allied forces.
The first convoys of those refusing to “reconcile” with the government begin leaving eastern Ghouta, with thousands in Harasta boarding buses headed to the rebel-held north.
Rebels in the Damascus suburbs of Arbin, Zamalka, Ein Tarma, and the Damascus Jobar neighborhood agree to a surrender deal, after heavy incendiary bombings on Arbin.
An interim agreement is reached for the evacuation of urgent humanitarian cases from Douma, while talks for final surrender continue between the Russian military and Jaysh al-Islam, the rebels in control of Douma.
After a breakdown in negotiations between the Russian military and Jaysh al-Islam, the Syrian government resumes its assault on Douma with heavy bombardments.
A chemical attack is launched on Douma, killing between forty and seventy people, in one of the deadliest chemical weapons attacks of the Syrian conflict.
Douma’s rebels agree to surrender and be displaced to the rebel-held north.
The first and last convoy of those refusing to “reconcile” with the government is dispatched to rebel-held Idlib. A total of 66,369 people were displaced from eastern Ghouta in this forcible population transfer operation.